Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surface-Neutralized HgCdSe Quantum Dots for High-Detectivity Infrared Photodetectors.

Nano letters·2026
Same author

Quantum Dot Encoding for In-Solution Single-Molecule Biomarker Counting in Metastatic Prostate Cancer.

ACS nano·2026
Same author

Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis.

Molecular medicine reports·2025
Same author

Quantum Dot Encoding for In-Solution Single-Molecule Biomarker Counting in Metastatic Prostate Cancer.

medRxiv : the preprint server for health sciences·2025
Same author

Tumor-targeting Cu<sup>2+</sup>/IR820-rich nanozymes to exert photothermal-reinforced reactive oxygen species production and dual glutathione scavenging for synergistic cancer therapy.

Journal of colloid and interface science·2025
Same author

Nanomedicine targeting PPAR in adipose tissue macrophages improves lipid metabolism and obesity-induced metabolic dysfunction.

Science advances·2025

Related Experiment Video

Updated: Aug 5, 2025

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

18.2K

Structural Design of Multidentate Copolymers as Compact Quantum Dot Coatings for Live-Cell Single-Particle Imaging.

Zhiyuan Han1, Rohit M Vaidya2, Opeyemi H Arogundade3

  • 1Department of Materials Science and Engineering and Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

Chemistry of Materials : a Publication of the American Chemical Society
|March 27, 2023
PubMed
Summary

Researchers developed smaller quantum dots (QDs) by optimizing polymer coatings. This enhances their ability to target specific molecules in cells, improving imaging and tracking for life science applications.

More Related Videos

Production and Targeting of Monovalent Quantum Dots
10:16

Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

25.6K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

7.8K

Related Experiment Videos

Last Updated: Aug 5, 2025

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

18.2K
Production and Targeting of Monovalent Quantum Dots
10:16

Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

25.6K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

7.8K

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Quantum dots (QDs) are semiconductor nanocrystals widely used as fluorescent emitters in life science analytical studies.
  • Their application in single-particle imaging and tracking within cells and tissues is significant.
  • Reducing QD hydrodynamic size is crucial for accessing sterically hindered biological targets.

Purpose of the Study:

  • To investigate how structural characteristics of linear multidentate copolymers influence the hydrodynamic size, colloidal stability, and biomolecular interactions of coated QDs.
  • To establish a design roadmap for next-generation QDs with sizes comparable to fluorescent proteins.

Main Methods:

  • Tuning copolymer composition, degree of polymerization, and hydrophilic group length.
  • Coating polymers on Cadmium Selenide (CdSe) and (core)shell (Mercury Cadmium Selenide)Cadmium Zinc Sulfide (HgCdSe)CdZnS QDs.
  • Utilizing quantitative single-molecule imaging assays in live neuron synapses.

Main Results:

  • A wide range of polymer structures and compositions yield stable colloidal QD dispersions.
  • Simultaneous minimization of hydrodynamic size and resistance to nonspecific binding requires a narrow range of properties: short polymers, balanced compositions, and small nanocrystals.
  • Size reduction progressively increased labeling specificity of neurotransmitter receptors in live neuron synapses.

Conclusions:

  • Structural characteristics of linear multidentate copolymers critically determine QD hydrodynamic size, stability, and interactions.
  • Achieving minimal hydrodynamic size and high specificity requires careful optimization of polymer properties and QD core size.
  • The findings provide a pathway for developing advanced QDs for enhanced live-cell biomolecular studies.