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Targeting FMRP: A new window for cancer immunotherapy
Yaguang Zhang1, Tong Wu1, Junhong Han1,2
1State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-Related Molecular Network West China Hospital Sichuan University Chengdu P. R. China.
Abstract:
FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues.FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes.FMRP-KO up-regulates tumor cell secretion of CCL7, which directly activates and recruits CD8+ T cells.FMRP-KO recruits CCR5 and CXCR4 receptor-positive CD8 T cells indirectly by promoting M1 macrophages to secrete CCL5, CXCL9, and CXCL10.
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