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The progress in the relationship between trace elements and acute lymphoblastic leukemia.

Jing Wang1,2,3, Pei Huang1, Changhui Lang1

  • 1Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Frontiers in Cell and Developmental Biology
|March 27, 2023
PubMed
Summary

Trace elements significantly impact human health and disease. This review explores the link between trace element levels and acute lymphoblastic leukemia (ALL), aiding diagnosis and treatment.

Keywords:
DNA synthesisacute lymphoblastic leukemiafree radicalgene mutationtrace elements

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Area of Science:

  • Biochemistry
  • Oncology
  • Human Physiology

Background:

  • Trace elements, though present in minute quantities, are crucial for human health.
  • Altered trace element levels are associated with various diseases, including cancers.
  • Acute lymphoblastic leukemia (ALL) is a significant hematological malignancy with potential links to trace element metabolism.

Purpose of the Study:

  • To review current research on the relationship between trace elements and acute lymphoblastic leukemia (ALL).
  • To explore how trace element dysregulation may influence ALL development and progression.
  • To provide insights into the role of trace elements in ALL diagnosis, treatment, and prevention.

Main Methods:

  • Literature review of studies investigating trace elements in ALL patients.
  • Analysis of research on trace element involvement in cell proliferation and DNA repair mechanisms.
  • Synthesis of findings linking trace element metabolism to ALL pathogenesis.

Main Results:

  • Evidence suggests altered trace element levels in ALL patients.
  • Trace element changes correlate with the efficacy of ALL treatments.
  • Trace elements play a role in DNA damage and repair, potentially influencing lymphoid precursor cell dynamics in ALL.

Conclusions:

  • Abnormal trace element metabolism is increasingly recognized as a factor in ALL.
  • Understanding these relationships can enhance diagnostic and therapeutic strategies for ALL.
  • Further research into trace elements offers potential for improved ALL prevention and management.