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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning
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Improved LSTM-based deep learning model for COVID-19 prediction using optimized approach.

Luyu Zhou1,2, Chun Zhao1, Ning Liu2

  • 1Department of Pharmacy, College of Biology, Hunan University, Changsha, Hunan 410082, China.

Engineering Applications of Artificial Intelligence
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Machine learning models, including Long Short-Term Memory (LSTM) networks, accurately forecast COVID-19 trends. These advanced models predict confirmed cases, deaths, and recoveries, aiding in impact assessments for infectious disease outbreaks.

Keywords:
COVID-19ForecastLong short-term memory (LSTM)Prediction

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Area of Science:

  • Epidemiology and Public Health
  • Computer Science and Machine Learning
  • Data Science and Predictive Analytics

Background:

  • Infectious disease epidemics, such as the COVID-19 pandemic, cause significant global economic and physical disruption.
  • Accurate forecasting of disease spread is crucial for effective public health interventions and resource allocation.
  • Machine learning models are increasingly utilized for improved prediction of epidemic trends.

Purpose of the Study:

  • To evaluate the performance of various time series forecasting models for predicting COVID-19 confirmed cases, deaths, and recoveries.
  • To compare the efficacy of Long Short-Term Memory (LSTM) based models against other machine learning approaches.
  • To assess the predictive capabilities of LSTM, Bidirectional LSTM (Bi-LSTM), and Gated Recurrent Unit (GRU) models.

Main Methods:

  • Time series prediction using LSTM, Bi-LSTM, GRU, and dense-LSTM models.
  • Evaluation of models on confirmed cases, deaths, and recoveries data from 12 major COVID-19 affected countries.
  • Performance metrics included Mean Absolute Error (MAE), Root Mean Square Error (RMSE), Median Absolute Error (MEDAE), and R2 score.
  • Implementation using Tensorflow 1.0.

Main Results:

  • LSTM-based models demonstrated strong performance in time series prediction of COVID-19 data.
  • Comparative analysis showed LSTM models to be highly effective compared to other machine learning models evaluated.
  • The models successfully forecasted annual trends, aiding in potential impact assessments.

Conclusions:

  • LSTM-based models are highly effective and among the most advanced for time series forecasting of infectious disease data.
  • The study validates the utility of deep learning approaches for predicting key COVID-19 metrics.
  • Forecasting models are essential tools for understanding and managing the impact of epidemics.