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Establishing cognitive baseline in three generations: Framingham Heart Study
Jin Yang1, Ting Fang Alvin Ang2,3, Sophia Lu4
1Department for Endemic Disease Control and Prevention Henan Provincial Center for Disease Control and Prevention Zhengzhou China.
Introduction:
Generational changes warrant recalibrating normative cognitive measures to detect changes indicative of dementia risk within each generation.
Methods:
We performed linear regressions to compare eight neuropsychological (NP) tests among three-generation cohorts at baseline in Framingham Heart Study (FHS, n = 4787) and conducted Cox regressions to investigate the relationships of NP tests with generation-specific dementia risk.
Results:
The FHS second and third generations performed better than the first generation for seven NP tests (0.14-0.81 standard deviation improvement, P ≤ .001) while the second and third generations performed similarly for six of eight NP tests (P > .05). One standard deviation better performance was associated with a higher reduction in incident dementia risk in the second than the first generation (35% vs. 24%, P interaction = .02) for the similarities test.
Discussion:
Our findings suggest cohort-based norms are needed for cognitive assessment for the diagnosis of cognitive impairment and dementia.
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