Application of low dose aspirin in pre-eclampsia

Area of Science:

• Obstetrics and Gynecology
• Pharmacology
• Cardiovascular Research

Background:

• Aspirin is utilized for cardiovascular disease prevention and in pregnancy to mitigate pre-eclampsia and fetal growth issues.
• The efficacy and safety of aspirin during pregnancy, particularly for pre-eclampsia, remain subjects of ongoing debate and research.
• Conflicting international guidelines highlight the lack of consensus on low-dose aspirin use in obstetric care.

Purpose of the Study:

• To review the current research on aspirin's role in pre-eclampsia prevention.
• To elucidate the mechanisms underlying aspirin's effects in pregnancy.
• To discuss the future applications and provide a basis for rational aspirin use in pregnant individuals.

Main Methods:

• Systematic review of existing literature on aspirin and pre-eclampsia.
• Analysis of studies investigating the impact of low-dose aspirin on pre-eclampsia morbidity.
• Synthesis of research progress, mechanistic insights, and clinical application prospects.

Main Results:

• Numerous studies since 1985 have investigated low-dose aspirin for pre-eclampsia prevention with inconclusive results.
• Variations in global guidelines underscore the lack of definitive evidence and consensus.
• Research continues to explore aspirin's potential benefits and risks in obstetric settings.

Conclusions:

• The use of aspirin in pregnancy for pre-eclampsia prevention requires further investigation to establish clear guidelines.
• Understanding aspirin's mechanism of action is crucial for optimizing its application.
• This review provides a theoretical framework to support evidence-based decision-making regarding aspirin use in pregnancy.