Related Experiment Video
Updated: Aug 5, 2025

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
Published on: June 24, 2019
Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis
Mengjie Liang1, Xingzhou Wang1, Daming Cai1
1Department of General Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Abstract:
Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably reside in tissues and have been revealed to be the most abundant memory T cell population in various tissues. They can be activated in the local microenvironment by infection or tumor cells and rapidly clean them up to restore homeostasis of local immunity in gastrointestinal tissues. Emerging evidence has shown that tissue-resident memory T cells have great potential to be mucosal guardians against gastrointestinal tumors. Therefore, they are considered potential immune markers for immunotherapy of gastrointestinal tumors and potential extraction objects for cell therapy with essential prospects in clinical translational therapy. This paper systematically reviews the role of tissue-resident memory T cells in gastrointestinal tumors and looks to the future of their prospect in immunotherapy to provide a reference for clinical application.
More Related Videos
Related Concept Videos
Cell-mediated Immune Responses
Tumor Immunotherapy
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Cells of the Adaptive Immune Response
Renewal of Intestinal Stem Cells
The Tumor Microenvironment

