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Updated: Aug 5, 2025

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Regulation of CD8 T cell by B-cells: A narrative review

Tess Van Meerhaeghe1,2, Antoine Néel2,3, Sophie Brouard2

  • 1Department of Nephrology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.

Frontiers in Immunology
|March 27, 2023
PubMed

Activation of CD4 T cells by B cells has been extensively studied, but B cell-regulated priming, proliferation, and survival of CD8 T cells remains controversial. B cells express high levels of MHC class I molecules and can potentially act as antigen-presenting cells (APCs) for CD8 T cells. Several in vivo studies in mice and humans demonstrate the role of B cells as modulators of CD8 T cell function in the context of viral infections, autoimmune diseases, cancer and allograft rejection. In addition, B-cell depletion therapies can lead to impaired CD8 T-cell responses. In this review, we attempt to answer 2 important questions: 1. the role of B cell antigen presentation and cytokine production in the regulation of CD8 T cell survival and cell fate determination, and 2. The role of B cells in the formation and maintenance of CD8 T cell memory.

Keywords:
B cellCD8 lymphocytes +auto-immunecrosstalkregulation

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