Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

62
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
62

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical characteristics and prognostic value of pre-retreatment plasma epstein-barr virus DNA in locoregional recurrent nasopharyngeal carcinoma.

Cancer medicine·2019
Same author

Correlation of sleep microstructure with daytime sleepiness and cognitive function in young and middle-aged adults with obstructive sleep apnea syndrome.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2019
Same author

Orbital-flop Induced Magnetoresistance Anisotropy in Rare Earth Monopnictide CeSb.

Nature communications·2019
Same author

Author Correction: Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer.

Cell death & disease·2019
Same author

A hybrid gene selection method based on gene scoring strategy and improved particle swarm optimization.

BMC bioinformatics·2019
Same author

TL1A modulates the severity of colitis by promoting Th9 differentiation and IL-9 secretion.

Life sciences·2019

Related Experiment Video

Updated: Aug 5, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

35.1K

Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19.

Wenhao Liu1,2, Fei Han2, Mengyao Wan1,2

  • 1Eight-year program of Clinical Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Frontiers in Immunology
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

This study reveals shared immune pathways and biomarkers between COVID-19 and ischemic stroke (IS). JAK2 is identified as a potential therapeutic target, offering insights into neurological complications of COVID-19.

Keywords:
COVID-19gene expression profilesimmune cell proportionimmune systemischemic stroke

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.4K
Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.4K

Related Experiment Videos

Last Updated: Aug 5, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

35.1K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.4K
Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.4K

Area of Science:

  • Neuroscience
  • Immunology
  • Genomics

Background:

  • COVID-19, primarily respiratory, presents neurological complications like ischemic stroke (IS).
  • Molecular mechanisms linking COVID-19 and IS remain poorly understood.
  • Transcriptomic analysis is crucial for identifying shared pathways and biomarkers.

Purpose of the Study:

  • To detect common pathways and molecular biomarkers in IS and COVID-19.
  • To elucidate the molecular mechanisms underlying the linkage between IS and COVID-19.
  • To identify potential therapeutic targets for both conditions.

Main Methods:

  • Transcriptomic analysis of eight Gene Expression Omnibus (GEO) datasets.
  • Analysis of 1191 samples from IS and COVID-19 patients.
  • Differential gene expression (DEG) analysis to identify shared mechanisms.

Main Results:

  • Immune-related pathways were significantly associated in both IS and COVID-19.
  • JAK2 identified as a hub gene, suggesting potential therapeutic value.
  • Decreased CD8+ T and T helper 2 cells correlated with NCR3 expression in both conditions.

Conclusions:

  • Transcriptomic analysis deepens understanding of common mechanisms between IS and COVID-19.
  • JAK2 and NCR3 represent promising therapeutic targets.
  • Findings may lead to effective treatments for neurological complications of COVID-19 and IS.