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Related Experiment Video

Updated: Aug 5, 2025

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
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Axial Axis Metastasis.

Marcio Fernando Aparecido de Moura1,2, Suely Akiko Nakagawa3, Diego Pereira Sanches4

  • 1Ortopedia Oncológica e Cirurgia da Coluna Vertebral, Hospital de Clínicas e Hospital do Trabalhador da Universidade Federal do Paraná, Curitiba, PR, Brasil.

Revista Brasileira De Ortopedia
|March 27, 2023
PubMed
Summary

Metastasis to the axial skeleton presents significant challenges for surgical and non-surgical treatments. Percutaneous techniques offer a viable option for local control in complex cases, particularly when combined with radiotherapy.

Keywords:
bone neoplasmspelvisspinespontaneous fracture

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Area of Science:

  • Oncology
  • Orthopedic Surgery
  • Radiotherapy

Background:

  • Axial skeleton metastasis poses challenges for current treatments.
  • Surgery offers pain relief and neurological preservation but doesn't fully resolve the issue.
  • Combined treatment modalities like chemotherapy, immunotherapy, and radiotherapy are often employed.

Purpose of the Study:

  • To review current surgical treatments for axial skeleton metastasis.
  • To highlight the role of percutaneous techniques in managing metastatic disease.
  • To assess treatment options in the context of radiotherapy and patient instability.

Main Methods:

  • Review of current surgical treatment modalities for spinal and pelvic metastasis.
  • Evaluation of percutaneous treatment options for metastatic disease.
  • Analysis of treatment efficacy in patients undergoing radiotherapy.

Main Results:

  • Surgery improves pain and preserves neurological status.
  • Percutaneous treatments are effective for local control in specific cases.
  • Percutaneous options are suitable for high-risk patients and those with instability, especially with radiotherapy.

Conclusions:

  • Axial skeleton metastasis remains a complex clinical challenge.
  • Percutaneous techniques represent a valuable approach for local control.
  • Treatment strategies must be individualized, considering patient risk and disease extent.