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Updated: Aug 5, 2025
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Peroxidase-like MoS2/Ag nanosheets with synergistically enhanced NIR-responsive antibacterial activities
Huiying Chen1,2, Xinshuo Zhao3, Bingbing Cui1,2
1Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Abstract:
Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS2) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of H2O2. The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS2 nanosheets, the MoS2/Ag nanosheets (denoted as MoS2/Ag NSs) exhibited better antibacterial performance against Staphylococcus aureus by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS2/Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS2/Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.
Insights
This study developed silver nanoparticle-loaded molybdenum disulfide nanosheets (MoS2/Ag NSs) for rapid, antibiotics-free bacterial inactivation. The material efficiently eliminates Staphylococcus aureus using reactive oxygen species under near-infrared light.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Antibiotic resistance poses a global health threat, necessitating alternative antimicrobial strategies.
- Developing effective, antibiotic-free materials for bacterial infection treatment is crucial.
Purpose of the Study:
- To construct and evaluate molybdenum disulfide (MoS2) nanosheets loaded with silver nanoparticles (Ag NPs) as an antibiotic-free antimicrobial agent.
- To investigate the antibacterial efficacy of MoS2/Ag nanosheets under near-infrared (NIR) laser irradiation in the presence of H2O2.
Main Methods:
- Synthesis of MoS2 nanosheets loaded with varying amounts of Ag NPs (MoS2/Ag NSs).
- Evaluation of the peroxidase-like and photodynamic properties of MoS2/Ag NSs.
- Assessment of antibacterial activity against Staphylococcus aureus using NIR laser irradiation and H2O2.
- Cell viability assays to determine cytotoxicity.
Main Results:
- MoS2/Ag NSs demonstrated efficient rapid inactivation of Staphylococcus aureus.
- The antibacterial performance was attributed to reactive oxygen species (ROS) generated via peroxidase-like catalysis and photodynamic effects.
- Antibacterial efficiency increased with higher silver content, and MoS2/Ag3 nanosheets showed negligible impact on cell growth.
Conclusions:
- MoS2/Ag NSs offer a promising antibiotic-free strategy for bacterial disinfection.
- The combined peroxidase-like and photodynamic properties contribute to potent antimicrobial activity.
- This approach could be a viable candidate for treating bacterial infections and other disinfection applications.
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