Natural products targeting cellular processes common in Parkinson's disease and multiple sclerosis
Xuxu Xu1,2, Chaowei Han1, Pengcheng Wang1
1Institute of Surface Analysis and Chemical Biology, University of Jinan, Jinan, Shangdong, China.
Frontiers in Neurology
|March 27, 2023
Summary
Natural products show promise for treating Parkinson's disease (PD) and multiple sclerosis (MS) by targeting shared neuroinflammatory and oxidative stress pathways. Some natural compounds effective for one neurodegenerative disease may be repurposed for the other.
Area of Science:
- Neuroscience
- Pharmacology
- Immunology
Background:
- Parkinson's disease (PD) and multiple sclerosis (MS) are distinct neurodegenerative disorders with differing primary pathologies.
- Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) dysfunction are common pathological mechanisms in both PD and MS.
- Current treatments for PD and MS have limitations, including low efficacy and adverse side effects.
Purpose of the Study:
- To review the therapeutic potential of natural products (NPs) for Parkinson's disease and multiple sclerosis.
- To highlight the neuroprotective and immune-regulating properties of NPs in preclinical models.
- To explore the repurposing of NPs across these two neurodegenerative diseases based on shared cellular processes.
Main Methods:
- Literature review of studies on natural compounds targeting cellular processes in PD and MS.
- Analysis of neuroprotective and immune-modulating effects of NPs in cellular and animal models.
- Comparative assessment of NP efficacy for shared pathological pathways in PD and MS.
Main Results:
- Numerous natural compounds exhibit neuroprotective and immune-regulating effects relevant to both PD and MS.
- Shared cellular mechanisms in PD and MS suggest potential for NP repurposing.
- Preclinical data support the application of specific NPs for common pathological hallmarks.
Conclusions:
- Natural products offer a promising avenue for developing novel therapeutics for Parkinson's disease and multiple sclerosis.
- The identified similarities between PD and MS pave the way for repurposing natural compounds.
- Further research into NPs can provide new insights for treating common neurodegenerative disease pathways.
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