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Systemic treatment for metastatic colorectal cancer

Wattana Leowattana1, Pathomthep Leowattana2, Tawithep Leowattana3

  • 1Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. wattana.leo@mahidol.ac.th.

World Journal of Gastroenterology
|March 27, 2023
PubMed

Insights

Advances in molecular technologies have improved metastatic colorectal cancer (mCRC) treatments. Personalized medicine, using biomarkers and advanced sequencing, enhances survival but non-metastatic disease still offers optimal outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Translational Medicine

Background:

  • Metastatic colorectal cancer (mCRC) treatment has seen significant advancements over the past two decades.
  • Numerous first-line treatment options are now available for mCRC patients.
  • The identification of prognostic and predictive biomarkers is crucial for effective CRC management.

Purpose of the Study:

  • To review the evolution of systemic treatments for first-line mCRC.
  • To discuss the role of molecular technologies and biomarkers in personalized medicine for mCRC.
  • To highlight the practical application of molecular biomarkers in clinical practice.

Main Methods:

  • Review of current literature on mCRC treatment strategies.
  • Analysis of advancements in molecular technologies like next-generation sequencing (NGS) and whole-exome sequencing (WES).
  • Examination of factors influencing adjuvant treatment decisions, including tumor stage and microsatellite instability (MSI).

Main Results:

  • Novel treatment choices, including chemotherapy, targeted therapy, and immunotherapy, have improved overall survival for mCRC patients.
  • Molecular technologies and biomarkers are increasingly vital for personalized treatment strategies.
  • Despite progress, survival outcomes remain superior for patients with non-metastatic disease.

Conclusions:

  • Personalized medicine, driven by molecular insights, is transforming mCRC care.
  • The integration of advanced sequencing technologies facilitates biomarker discovery for tailored therapies.
  • Continued research and clinical application of biomarkers are essential for further improving mCRC patient outcomes.
Keywords:
BiomarkersChemotherapyImmunotherapyMetastatic colorectal cancerPersonalized medicineSystemic treatmentTargeted therapy

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