2D-nanomaterials for AKI treatment
Qiaohui Chen1,2, Xiaoyuan Wang2,3, Chao Yuan2,3
1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Frontiers in Bioengineering and Biotechnology
|March 27, 2023
Summary
Two-dimensional nanomaterials offer a promising new approach to treating acute kidney injury (AKI). These advanced materials show significant advantages over conventional therapies for managing kidney damage caused by oxidative stress.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nephrology
Background:
- Acute kidney injury (AKI) poses significant risks to hospitalized patients, characterized by high morbidity, mortality, and poor prognosis.
- Redox imbalance, driven by reactive oxygen species in renal tubules, is a primary cause of kidney damage in AKI.
- Conventional antioxidant drugs have limited efficacy in AKI management, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review recent advancements in the application of two-dimensional (2D) nanomaterials for treating AKI.
- To highlight the therapeutic potential of 2D nanomaterials in overcoming the limitations of current AKI treatments.
- To discuss future opportunities and challenges in developing 2D nanomaterial-based therapies for AKI.
Main Methods:
- Review of recent scientific literature on 2D nanomaterials for AKI therapy.
- Focus on specific 2D nanomaterials such as DNA origami, germanene, and MXene.
- Analysis of the unique properties of 2D nanomaterials, including their ultrathin structure, large surface area, and kidney targeting capabilities.
Main Results:
- 2D nanomaterials demonstrate significant advantages in AKI therapy due to their unique structural and physicochemical properties.
- Specific examples like DNA origami, germanene, and MXene show promise in preclinical AKI models.
- Nanotechnology-mediated antioxidant therapies offer a potent strategy for AKI management.
Conclusions:
- 2D nanomaterials represent a promising frontier for developing effective AKI treatments.
- Further research into novel 2D nanomaterials is crucial for advancing AKI therapy.
- This review provides insights and theoretical support for future development in the field of 2D nanomaterials for AKI.
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