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Bayesian clustering of multiple zero-inflated outcomes.

Beatrice Franzolini1, Andrea Cremaschi1, Willem van den Boom2

  • 1Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a new Bayesian method to cluster subjects with excess-zero count data from multiple processes. The approach effectively identifies patterns in zero-inflated data, improving subject clustering.

Keywords:
conditional algorithmenriched priorsexcess-of-zeros datafinite mixtureshurdle modelnested clustering

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Area of Science:

  • Statistics
  • Computational Statistics
  • Bayesian Inference

Background:

  • Many real-world applications involve count data with an excess proportion of zeros.
  • Traditional models may not adequately capture the complexity of multiple, related zero-inflated count processes.
  • Clustering subjects based on these complex count patterns is a significant challenge.

Purpose of the Study:

  • To develop a novel Bayesian approach for clustering subjects from multiple zero-inflated count processes.
  • To propose a flexible joint model that handles excess zeros and underlying count distributions.
  • To enable a two-level clustering based on zero-inflation patterns and sampling distributions.

Main Methods:

  • A joint hurdle model is specified for multiple zero-inflated count processes, each using a shifted Negative Binomial distribution.
  • An enriched finite mixture model with a random number of components is used for flexible modeling of subject-specific parameters.
  • Posterior inference is conducted using specialized Markov chain Monte Carlo (MCMC) algorithms.

Main Results:

  • The proposed Bayesian method effectively clusters subjects based on both zero/non-zero patterns and the underlying count distributions.
  • The model allows for conditional independence between processes, significantly reducing parameter complexity compared to multivariate methods.
  • Demonstrated application on WhatsApp usage data showcases the practical utility of the approach.

Conclusions:

  • The novel Bayesian framework provides a powerful tool for analyzing and clustering complex zero-inflated count data from multiple sources.
  • The two-level clustering mechanism offers deeper insights into subject heterogeneity.
  • This approach advances the analysis of multivariate count data in various scientific domains.