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Mucormycosis, past and present: a comprehensive review

Ishita Gupta1, Pritika Baranwal1, Gagandeep Singh2

  • 1Department of Microbiology, Ram Lal Anand College, University of Delhi, Benito Juarez Road, New Delhi, 110021, India.

Future Microbiology
|March 27, 2023
PubMed

Insights

Mucormycosis, a fungal infection, surged during the COVID-19 pandemic. This overview details COVID-19-associated mucormycosis (CAM) epidemiology, risk factors, and management strategies.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Mucormycosis is an opportunistic angioinvasive fungal infection.
  • Risk factors include diabetes, neutropenia, corticosteroid use, transplantation, and immunosuppression.
  • Its incidence significantly increased during the COVID-19 pandemic.

Purpose of the Study:

  • To provide an overview of mucormycosis epidemiology and prevalence.
  • To examine factors contributing to COVID-19-associated mucormycosis (CAM).
  • To review regulatory actions, diagnostic tools, and CAM management.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of pre- and post-COVID-19 epidemiological data.
  • Examination of regulatory responses and clinical management strategies.

Main Results:

  • Significant rise in mucormycosis cases linked to COVID-19.
  • Identification of key predisposing factors exacerbated by the pandemic.
  • Overview of established and emerging diagnostic and treatment protocols.

Conclusions:

  • Mucormycosis, particularly CAM, requires urgent attention.
  • Coordinated scientific and medical efforts are crucial to reduce morbidity and mortality.
  • Effective management strategies are essential for combating this emerging infection.
Keywords:
CAMCOVID-19-associated mucormycosisangioinvasionblack fungusdiagnosisepidemiologyinvasive fungal diseasemucormycosispathogenesispost-COVID-19 complicationstreatment

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