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Electrocardiogram to Determine Mitral and Aortic Valve Opening and Closure
M Rifqi Aufan1, Zachary T Jost2, Neal J Miller2
1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Cardiovascular Engineering and Technology
|March 27, 2023
Summary
Electrocardiogram (ECG) features accurately estimate aortic and mitral valve timing, offering valuable hemodynamic insights. This non-invasive method provides reliable cardiac valve timing comparable to Doppler echocardiography.
Area of Science:
- Cardiology
- Physiology
- Medical Imaging
Background:
- Accurate cardiac valve timing is crucial for understanding cardiac physiology.
- The relationship between electrocardiogram (ECG) signals and valve motion is not well-defined.
- Doppler echocardiography (DE) is the gold standard for assessing valve timing.
Purpose of the Study:
- To evaluate the accuracy of ECG-derived cardiac valve timing.
- To compare ECG-based estimations with gold-standard DE measurements.
- To investigate the feasibility of using ECG alone for valve timing.
Main Methods:
- Simultaneous ECG and DE recordings were obtained from 37 patients.
- ECG features (QRS, T, P waves) were analyzed to estimate aortic and mitral valve opening/closure.
- A model was developed using a derivation set and validated on a separate set.
Main Results:
- The ECG-based model accurately estimated aortic and mitral valve timing with a median absolute error of 19 ms compared to DE.
- Fixed offsets were identified between specific ECG waves and valve events.
- Higher errors were observed for right-sided valves (tricuspid and pulmonic).
Conclusions:
- ECG features provide a reliable method for estimating aortic and mitral valve timing.
- This approach allows hemodynamic information to be obtained non-invasively.
- ECG offers a valuable, accessible alternative for cardiac valve timing assessment.
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