Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Shapes01:18

Molecular Shapes

57.1K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
57.1K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

60.8K
Dipole Moment of a Molecule
60.8K
VSEPR Theory02:37

VSEPR Theory

9.7K
Valence shell electron-pair repulsion theory (VSEPR theory) enables us to predict the molecular structure around a central atom from an examination of the number of bonds and lone electron pairs in its Lewis structure. The VSEPR model assumes that electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between these electron pairs by maximizing the distance between them. The electrons in the valence shell of a central atom form either bonding...
9.7K
VSEPR Theory and the Basic Shapes02:52

VSEPR Theory and the Basic Shapes

68.7K
Overview of VSEPR Theory
68.7K
Molecular Orbital Theory I02:35

Molecular Orbital Theory I

32.4K
Overview of Molecular Orbital Theory
32.4K
Molecular Models02:00

Molecular Models

38.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
38.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electronic coupling in a synthetic model of the Cu-cofactor unit of the P<sub>M</sub> state in cytochrome <i>c</i> oxidase.

Chemical communications (Cambridge, England)·2026
Same author

<i>N</i>-Arylsulfonamidocalix[4]arenes with narrow pH-responsive binding near neutral pH.

Chemical science·2025
Same author

Synthesis of Indoles through C2-C3 Bond Formation Using Lawesson's Reagent.

The Journal of organic chemistry·2025
Same author

Probing the Antiaromaticity and Coordination Chemistry of Bowl-Shaped Zinc(II) Norcorrole.

Inorganic chemistry·2024
Same author

Ruthenium(II) Complexes of a Xanthene-Spanned Dicarbene Ligand.

Inorganic chemistry·2023
Same author

Structure of racemic duloxetine hydro-chloride.

Acta crystallographica. Section E, Crystallographic communications·2023
Same journal

Mapping structure-property relationships in a 6-oxo-verdazyl radical by variable pressure crystallography and density functional theory.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same journal

High-pressure and high-temperature polymorphism of Na<sub>2</sub>CO<sub>3</sub> up to 10 GPa.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same journal

Thermostructural and elastic properties of Ni<sub>3</sub>V<sub>2</sub>O<sub>8</sub>, exhibiting a kagome layer arrangement: experimental study in the range 15-1323 K.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same journal

Interaction Analysis using the Cambridge Structural Database - rapid access to intermolecular hydrogen-bond frequencies and uses for coformer selection.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same journal

Deciphering unusually large modulations in two related organic hydroxy channel structures.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same journal

Random in-plane translational stacking faults in the van der Waals superlattice Ba<sub>6</sub>Nb<sub>11</sub>Se<sub>28</sub>.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
See all related articles

Related Experiment Video

Updated: Aug 5, 2025

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

10.1K

How much do molecular shapes matter?

Mohan Bhadbhade1

  • 1Mark Wainwright Analytical Centre, The University of New South Wales (UNSW), Sydney, NSW 2052, Australia.

Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Molecular shape significantly influences how drug molecules like nifedipine (NIF) associate in crystals. This study explores the impact of T-shaped molecular geometry on crystal packing patterns.

Keywords:
nifedipinepharmaceuticalpolymorphismsolvate

More Related Videos

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
11:58

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes

Published on: January 30, 2019

8.4K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.6K

Related Experiment Videos

Last Updated: Aug 5, 2025

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

10.1K
Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes
11:58

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes

Published on: January 30, 2019

8.4K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.6K

Area of Science:

  • Crystallography
  • Solid-state chemistry
  • Drug design

Background:

  • Nifedipine (NIF) is an L-type calcium channel antagonist.
  • Previous research (Jones et al., 2023) identified similar packing patterns in solvated NIF structures.
  • The T-shape of the NIF molecule is a notable geometric feature.

Purpose of the Study:

  • To investigate the role of molecular shape in the crystal packing of nifedipine.
  • To determine how the T-shaped geometry of NIF influences its intermolecular associations in crystalline states.
  • To correlate molecular geometry with observed crystal structure patterns.

Main Methods:

  • Analysis of crystal structures of nifedipine and related compounds.
  • Computational modeling to assess shape-dependent interactions.
  • Comparison of packing motifs across different solvated forms.

Main Results:

  • The T-shaped molecular geometry of nifedipine plays a crucial role in directing its crystal packing.
  • Specific intermolecular interactions, influenced by the molecular shape, lead to recurring structural patterns.
  • Deviations from ideal T-shape can alter packing arrangements.

Conclusions:

  • Molecular shape is a critical determinant of crystal structure in nifedipine.
  • Understanding shape-dependent packing is essential for predicting and controlling solid-state properties of drugs.
  • This research provides insights into rational crystal engineering for pharmaceutical applications.