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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

648

Allosteric inactivation of an engineered optogenetic GTPase

Abha Jain1, Nikolay V Dokholyan2,3, Andrew L Lee1

  • 1Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Proceedings of the National Academy of Sciences of the United States of America
|March 27, 2023
PubMed
Summary

Optogenetics uses light to control protein function. Researchers engineered a bi-switchable fusion protein, Cdc42Lov, demonstrating light-induced allosteric inhibition of Cdc42 signaling pathways via NMR spectroscopy.

Keywords:
Cdc42NMROptogeneticallostericprotein engineering

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