Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

46
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
46
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

35
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
35
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

43
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
43
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

50
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
50
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

41
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
41
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

38
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LATAM-AKID registry: an international multicentre, observational study of acute kidney injury requiring dialysis in Latin America.

BMJ open·2026
Same author

Renal Resistive Index in Severe Preeclampsia: Correlation With Glomerular Filtration Rate and Diagnostic Accuracy for Acute Kidney Injury.

International journal of nephrology·2026
Same author

Impact of hemoglobin increase in patients with acute kidney injury and severe anemia on major adverse kidney events.

Renal failure·2026
Same author

Nutritional therapy in critically ill patients with acute kidney injury on renal replacement therapy: An evidence review.

Nefrologia·2026
Same author

Decision making in vascular access: International perspectives on dialysis catheter choice.

The journal of vascular access·2026
Same author

Kidney health without borders: a multilingual kidney education platform.

Kidney international·2026
Same journal

SIRT6 attenuates angiotensin II-induced podocyte cholesterol accumulation and injury via negative modulation of SREBP2.

Kidney & blood pressure research·2026
Same journal

Epidemiology and multimorbidity in hemodialysis patients at a tertiary care center in northern Mexico: implications for hospital-based adverse outcomes.

Kidney & blood pressure research·2026
Same journal

The inflammatory milieu exacerbates Anemia of CKD:  From the gut-kidney axis to bone marrow hematopoiesis inhibition.

Kidney & blood pressure research·2026
Same journal

Cystine-binding medication is poorly accessible for the treatment of cystinuria.

Kidney & blood pressure research·2026
Same journal

Infective endocarditis-associated glomerulonephritis caused by Streptococcus cristatus: A Case Report.

Kidney & blood pressure research·2026
Same journal

Simplified Subjective Global Assessment at Hemodialysis Initiation and Its Association with 2-Year Mortality and Hospitalization.

Kidney & blood pressure research·2026
See all related articles

Related Experiment Video

Updated: Aug 5, 2025

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.2K

Urea Reduction in Acute Kidney Injury and Mortality Risk.

Jonathan S Chávez-Íñiguez1,2, Pablo Maggiani-Aguilera3, David González-Barajas1,2

  • 1Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Kidney & Blood Pressure Research
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Reducing serum urea levels in acute kidney injury (AKI) patients is linked to better survival. A urea reduction ratio (UXR) greater than 25% significantly improves outcomes, with the best survival seen in patients with a UXR over 50%.

Keywords:
Acute kidney injuryMortalityUreaUremic syndrome

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.5K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.3K

Related Experiment Videos

Last Updated: Aug 5, 2025

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.2K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.5K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.3K

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Toxicology

Background:

  • Urea is a known toxin in acute kidney injury (AKI).
  • The study hypothesizes that reducing serum urea levels may improve clinical outcomes in AKI patients.
  • The association between urea reduction and mortality in AKI was examined.

Purpose of the Study:

  • To investigate the relationship between the urea reduction ratio (UXR) and mortality in patients with AKI.
  • To identify patient characteristics associated with achieving a high UXR (>50%).
  • To explore the impact of kidney replacement therapy (KRT) modality on UXR and the association between serum creatinine (sCr) changes and mortality.

Main Methods:

  • Retrospective cohort study of 651 AKI patients.
  • Patients were grouped based on their UXR (0%, 1-25%, 26-50%, >50%) calculated from peak urea levels to day 10 or discharge/death.
  • Primary endpoint was the association between UXR and mortality; secondary endpoints included factors influencing UXR and sCr changes.

Main Results:

  • A trend towards decreased mortality risk was observed with increasing UXR.
  • Patients with UXR >50% had the highest survival rate (94.3%), while those with 0% UXR had the highest mortality (72.1%).
  • After adjustment, mortality was higher for UXR <25% (OR: 1.20); high UXR was linked to uremic syndrome or obstructive nephropathy; sCr changes also correlated with mortality risk.

Conclusions:

  • The percent decrease in UXR from admission is associated with a stratified risk of death in AKI patients.
  • Achieving a UXR >25% was associated with improved outcomes.
  • A greater magnitude of urea reduction correlates with enhanced patient survival in AKI.