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Reclassifying hemophilia to include the definition of outcomes and phenotype as new targets

Jecko Thachil1, Jean M Connors2, Johnny Mahlangu3

  • 1Department of Haematology, Manchester University Hospitals, Oxford Road, Manchester, UK.

Journal of Thrombosis and Haemostasis : JTH
|March 27, 2023
PubMed

Hemophilia is classified into mild, moderate, and severe based on coagulation factor activity levels. Factor replacement and prophylaxis regimens in persons with hemophilia have helped to reduce bleeding and its related complications. With several newer treatments, some already approved and others soon to be, there may be a need to consider health-related quality of life in addition to bleed prevention as the goals of providing comprehensive care to persons with hemophilia. In this article, we discussed the reasons why such an approach may be relevant and call for the International Society of Thrombosis and Haemostasis to revisit the current classification of hemophilia.

Keywords:
bleedingclassificationhemophiliasymptoms

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