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Updated: Aug 5, 2025

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

A consensus protocol for functional connectivity analysis in the rat brain.

Joanes Grandjean^1,2, Gabriel Desrosiers-Gregoire^3,4, Cynthia Anckaerts^5,6

¹Donders Institute for Brain, Behaviour, and Cognition, Radboud University, Nijmegen, The Netherlands. joanes.grandjean@radboudumc.nl.

Nature Neuroscience

|March 27, 2023

Summary

This summary is machine-generated.

Researchers developed StandardRat, a consensus functional magnetic resonance imaging protocol for rats, improving the reliability of brain connectivity studies across multiple research centers. This standardized approach enhances data comparability in neuroscience research.

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Area of Science:

Neuroscience
Neuroimaging
Animal Models

Background:

Task-free functional connectivity in animal models is crucial for understanding brain networks under controlled conditions.
Current variations in animal imaging protocols hinder data comparison and integration across studies.

Purpose of the Study:

To introduce StandardRat, a consensus functional magnetic resonance imaging (fMRI) acquisition protocol for rats.
To establish a reproducible analysis pipeline for rat fMRI data.
To enhance the comparability and reliability of functional connectivity findings in rat models.

Main Methods:

Aggregated 65 functional imaging datasets from 46 centers to inform protocol development.
Developed and tested a consensus rat fMRI acquisition protocol (StandardRat) across 20 centers.
Created a reproducible data analysis pipeline for diverse rat fMRI protocols.

Main Results:

The standardized protocol demonstrated enhanced detection of biologically plausible functional connectivity patterns.
The developed pipeline identified experimental and processing parameters for robust functional connectivity detection.
Significant improvement in the consistency of functional connectivity results across centers using the StandardRat protocol.

Conclusions:

StandardRat provides a standardized framework for rat fMRI acquisition, promoting interoperability.
The shared protocol and pipeline facilitate cooperation and data integration in rodent neuroscience.
This initiative aims to advance the understanding of brain connectivity by enabling robust cross-center comparisons.