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Published on: February 15, 2022
Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases
Meng-Juan Lin1, Shi-Liang Hu2, Ying Tian3
1Department of Physiology, Institute of Neuroscience Research, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Abstract:
Vascular diseases are a major threat to human health, characterized by high rates of morbidity, mortality, and disability. VSMC senescence contributes to dramatic changes in vascular morphology, structure, and function. A growing number of studies suggest that VSMC senescence is an important pathophysiological mechanism for the development of vascular diseases, including pulmonary hypertension, atherosclerosis, aneurysm, and hypertension. This review summarizes the important role of VSMC senescence and senescence-associated secretory phenotype (SASP) secreted by senescent VSMCs in the pathophysiological process of vascular diseases. Meanwhile, it concludes the progress of antisenescence therapy targeting VSMC senescence or SASP, which provides new strategies for the prevention and treatment of vascular diseases.
Insights
Vascular smooth muscle cell (VSMC) senescence drives vascular diseases. Targeting VSMC senescence and its secretory phenotype offers new therapeutic strategies for preventing and treating these conditions.
Area of Science:
- Cardiovascular Biology
- Aging Research
- Pathophysiology
Background:
- Vascular diseases pose significant health risks, with high morbidity and mortality.
- Vascular smooth muscle cell (VSMC) senescence alters vascular structure and function.
- VSMC senescence is implicated in various vascular diseases like pulmonary hypertension and atherosclerosis.
Purpose of the Study:
- To review the role of VSMC senescence and its secretory phenotype (SASP) in vascular disease pathogenesis.
- To summarize advancements in antisenescence therapies targeting VSMC senescence and SASP.
Main Methods:
- Literature review of studies on VSMC senescence and vascular diseases.
- Analysis of the pathophysiological mechanisms involving VSMC senescence and SASP.
- Evaluation of current and emerging antisenescence therapeutic strategies.
Main Results:
- VSMC senescence significantly contributes to the development and progression of vascular diseases.
- The senescence-associated secretory phenotype (SASP) secreted by senescent VSMCs plays a crucial role in vascular pathology.
- Antisenescence therapies targeting VSMC senescence or SASP show promise.
Conclusions:
- VSMC senescence is a key driver of vascular disease.
- Targeting VSMC senescence and SASP presents novel therapeutic avenues.
- Antisenescence approaches offer potential for preventing and treating vascular diseases.
