Obese asthma phenotypes display distinct plasma biomarker profiles
Sophia Björkander1, Susanna Klevebro1,2, Natalia Hernandez-Pacheco1,3
1Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Clinical and Translational Allergy
|March 28, 2023
Summary
Asthma in obese individuals shows distinct inflammation markers compared to lean asthmatics. Identifying these plasma protein differences is key for tailored asthma treatments.
Area of Science:
- Immunology
- Pulmonology
- Biomarker Discovery
Background:
- Obese asthma is a complex condition requiring further pathophysiological understanding.
- This study investigates inflammation-related plasma biomarkers in lean versus overweight/obese asthma phenotypes.
Purpose of the Study:
- To identify distinct plasma protein profiles associated with asthma in lean and overweight/obese individuals.
- To explore how overweight/obesity influences the relationship between asthma and specific protein biomarkers.
Main Methods:
- Analysis of plasma protein levels (n=92) from the population-based BAMSE cohort (2069 participants aged 24-26).
- Stratification of participants into lean asthma, lean controls, overweight/obese asthma, and overweight/obese controls.
- Utilized the Olink Proseek Multiplex Inflammation panel for protein quantification.
Main Results:
- 41 out of 92 proteins were associated with either lean or overweight/obese asthma.
- Overweight/obesity status was a significant factor, with many proteins linked to obesity itself.
- Specific proteins like Beta-nerve growth factor (BetaNGF) and interleukin 5 (IL-5) were uniquely associated with lean or overweight/obese asthma, respectively.
- Interleukin-6 (IL-6) showed association with non-allergic asthma in the overweight/obese group.
Conclusions:
- Distinct plasma protein phenotypes exist between lean and overweight/obese asthmatics.
- These identified biomarkers may inform the development of targeted therapeutic strategies for different asthma phenotypes.
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