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Updated: Aug 5, 2025

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
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Subacute Combined Degeneration of the Spinal Cord Secondary to Nitrous Oxide Abuse

Aamir Khan1, Ayesha Zafar2, Hira Hamid3

  • 1Neurology, Queen Elizabeth Hospital Birmingham, Birmingham, GBR.

Cureus
|March 28, 2023
PubMed

Here, we report a case of subacute combined degeneration (SCD) of the spinal cord in the setting of nitrous oxide poisoning seen at the Medical Ward, Queen Elizabeth Hospital Birmingham Our patient was a 28-year-old lady who presented with impaired sensations in the lower limbs and difficulty walking for approximately one and a half months. Her clinical symptoms did not match common neurological conditions. Upon detailed history, she revealed that she had been frequently using nitrous oxide recreationally for several years. Although her baseline investigations were normal, her magnetic resonance imaging (MRI) of the spine showed bilateral symmetrical T2 hyperintense signal changes in the dorsal columns extending from C2 to C6 spinal segment. Based on history, clinical findings, and MRI of the cervical spine, the diagnosis of SCD of the spinal cord was made, and her symptoms fully resolved with treatment.

Keywords:
methioninemrinitrous oxidescidvitamin b12

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