Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antidiarrhoeal agents and laxatives: changing concepts.

E Fingl, J W Freston

    Clinics in Gastroenterology
    |January 1, 1979
    PubMed
    Summary

    Altered intestinal electrolyte transport is key to understanding diarrhea and constipation. Research into antidiarrheal agents and laxative mechanisms continues, focusing on improving bowel motility and treating constipation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Changes of gastric histology in patients with erosive oesophagitis receiving long-term lansoprazole maintenance therapy.

    Alimentary pharmacology & therapeutics·2010
    Same author

    The clinical safety of long-term lansoprazole for the maintenance of healed erosive oesophagitis.

    Alimentary pharmacology & therapeutics·2009
    Same author

    Rating the severity of the medical consequences of drug-induced liver injury.

    Regulatory toxicology and pharmacology : RTP·2005
    Same author

    A novel option in proton pump inhibitor dosing: lansoprazole orally disintegrating tablet dispersed in water and administered via nasogastric tube.

    Alimentary pharmacology & therapeutics·2004
    Same author

    Evaluation of the pharmacokinetics and pharmacodynamics of intravenous lansoprazole.

    Alimentary pharmacology & therapeutics·2004
    Same author

    Review article: approaches to the long-term management of adults with GERD-proton pump inhibitor therapy, laparoscopic fundoplication or endoscopic therapy?

    Alimentary pharmacology & therapeutics·2004

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Altered intestinal electrolyte transport (decreased absorption/increased secretion) is a primary factor in many diarrheal conditions.
    • This understanding influences the development of new antidiarrheal agents and research into adsorbents.
    • While altered electrolyte transport also affects laxative action, non-pharmacological methods are emphasized for constipation.

    Purpose of the Study:

    • To explore the role of intestinal electrolyte transport in diarrhea and constipation.
    • To discuss the implications for developing antidiarrheal agents.
    • To highlight ongoing research into laxative mechanisms and their impact on bowel motility.

    Main Methods:

    • Review of existing scientific literature on intestinal electrolyte transport.
    • Analysis of the mechanisms of action for antidiarrheal agents and laxatives.
    • Discussion of the pathogenesis of constipation and bowel motility disorders.

    Main Results:

    • Intestinal electrolyte transport is a critical target for antidiarrheal drug development.
    • Adsorbent agents remain of interest despite limited proof of efficacy.
    • Laxative research is increasingly focused on motility and constipation pathogenesis.

    Conclusions:

    • Understanding electrolyte transport is crucial for managing diarrhea.
    • Further research into laxatives may refine treatments for constipation and motility issues.
    • Non-pharmacological approaches are primary for functional constipation management.

    Related Experiment Videos