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Polymorphic phase behavior of platelet-activating factor.

C Huang, J T Mason, F A Stephenson

    Biophysical Journal
    |March 1, 1986
    PubMed
    Summary
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    This study reveals two key thermal phase transitions in platelet-activating factor (PAF) dispersions upon heating. These transitions involve structural changes from gel phases to vesicles and then to micelles.

    Area of Science:

    • Biophysical Chemistry
    • Materials Science
    • Spectroscopy

    Background:

    • Platelet-activating factor (PAF) is a biologically active phospholipid.
    • Understanding the phase behavior of PAF in aqueous dispersions is crucial for its applications.
    • Chemically synthesized PAF, 1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine, was studied.

    Purpose of the Study:

    • To investigate the thermal phase transitions of aqueous PAF dispersions.
    • To characterize the molecular ordering and packing structure during these transitions.
    • To compare the behavior of PAF dispersions with related phospholipids.

    Main Methods:

    • Vibrational Raman spectroscopy.
    • 31P Nuclear Magnetic Resonance (NMR) spectroscopy.

    Related Experiment Videos

  • Temperature-dependent studies of aqueous dispersions.

    • Main Results:

    • Two distinct thermal phase transitions were observed between -7 and 30 degrees C.
    • The transitions occurred at approximately 9.2 and 18.4 degrees C upon heating.
    • The low-temperature transition involved a change from interdigitated lamellar gel (II) to gel (I) phase, forming small bilayer vesicles.
    • The high-temperature transition shifted from interdigitated lamellar gel (I) to a micellar phase.
    • The interdigitated lamellar gel (I) phase appears unique to C(18)/PAF dispersions.

    Conclusions:

    • The study elucidates the complex phase behavior of PAF in water.
    • Specific structural rearrangements occur during thermal transitions, impacting vesicle and micellar formation.
    • The unique interdigitated lamellar gel (I) phase highlights distinct properties of PAF compared to other phospholipids.