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Intraocular pressure variation from ocular compression in low and high myopia.

Fang-Yu Xu1, Andrew Kc Lam1

  • 1School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

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|March 28, 2023
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Summary

Intraocular pressure (IOP) changes during ocular compression differ between low and high myopia. Low myopes exhibit faster IOP decay and recovery, suggesting distinct aqueous humor dynamics.

Keywords:
Aqueous humour dynamicintraocular pressureocular compression

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Area of Science:

  • Ophthalmology
  • Physiology

Background:

  • Ocular compression monitoring of intraocular pressure (IOP) changes offers insights into aqueous humor dynamics.
  • Previous studies focused on lamina cribrosa deformation and single post-compression IOP measurements, neglecting dynamic IOP changes.

Purpose of the Study:

  • To evaluate intraocular pressure (IOP) changes during and after acute ocular compression.
  • To compare these IOP dynamics between individuals with low myopia and high myopia.

Main Methods:

  • Age-matched cohorts of low and high myopes underwent ocular compression for 2 minutes.
  • Intraocular pressure (IOP) was measured at baseline, during compression at 30-second intervals, and during a 10-minute recovery phase using rebound tonometry.

Main Results:

  • Both low and high myopes showed similar baseline IOP and peak IOP during compression.
  • Low myopes demonstrated a significantly faster rate of IOP decay during compression (-3.24 mmHg/min vs. -2.58 mmHg/min).
  • Following compression release, low myopes' IOP returned to baseline faster (360s) than high myopes (510s).

Conclusions:

  • Single post-compression IOP measurements may underestimate the full impact of IOP fluctuations.
  • Dynamic IOP monitoring during and after ocular compression provides valuable data on aqueous humor outflow facilities.
  • Differences in IOP response highlight potential variations in ocular biomechanics between low and high myopia.