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Related Experiment Video

Updated: Aug 5, 2025

Retzius-Sparing Robot-Assisted Radical Prostatectomy
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Management of Recurrent Retroperitoneal Sarcoma.

Joshua S Jolissaint1, Chandrajit P Raut1,2, Mark Fairweather1,2

  • 1Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Current Oncology (Toronto, Ont.)
|March 28, 2023
PubMed
Summary

Recurrence of retroperitoneal sarcoma is common and depends on histology. Surgical resection offers the best survival benefit for recurrent disease, emphasizing multidisciplinary care at specialized centers.

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Enhanced Recovery After Surgery (ERAS) Outcomes After Liver and Pancreas Surgery Based on Regional Perioperative Pain Modalities.

Cureus·2026
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New Paradigms of Cancer Require New Language: A Qualitative Study Exploring Language for Non-Curative Non-Palliative Cancer Surgery.

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Dendritic cell redundancy enables priming of anti-tumor CD4<sup>+</sup> T cells in pancreatic cancer.

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Bayesian sequential learning for prognostication in extremity soft tissue sarcoma (BayeSarc): a retrospective, multicentre cohort study.

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Preoperative Radiotherapy and Postoperative Complications Among Patients with Primary Retroperitoneal Sarcoma: A Post Hoc Analysis of the EORTC-62092 (STRASS) Phase 3 Randomized Clinical Trial.

Annals of surgery·2026

Area of Science:

  • Oncology
  • Surgical Oncology
  • Sarcoma Research

Background:

  • Retroperitoneal sarcoma recurrence post-resection is frequent.
  • Histological subtype influences recurrence patterns, with liposarcoma favoring locoregional recurrence and leiomyosarcoma distant metastases.
  • Current data on radiotherapy and chemotherapy for recurrence are limited.

Purpose of the Study:

  • To analyze recurrence patterns and outcomes after retroperitoneal sarcoma resection.
  • To evaluate the impact of histology on recurrence sites.
  • To assess the role of surgery and other treatments in managing recurrent retroperitoneal sarcoma.

Main Methods:

  • Retrospective analysis of patients with retroperitoneal sarcoma.
  • Review of recurrence patterns based on histological subtype.
Keywords:
recurrentretroperitonealsarcomasurgery

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  • Evaluation of treatment outcomes, including surgery, radiotherapy, and chemotherapy.
  • Assessment of survival data for recurrent disease.

    • Main Results:

    • Recurrence rates vary significantly by histological subtype.
    • Well-differentiated liposarcoma commonly recurs locoregionally.
    • Leiomyosarcoma is more prone to distant metastatic recurrence.
    • Surgery for locally recurrent disease shows survival benefit in selected patients.
    • Resection of limited distant metastases may also be associated with improved survival.

    Conclusions:

    • Histology is a critical determinant of retroperitoneal sarcoma recurrence patterns.
    • Multidisciplinary evaluation at high-volume sarcoma centers is essential for managing complex recurrent cases.
    • Surgical management, including for locally recurrent and limited metastatic disease, is associated with improved survival.