Vitamin D and Multiple Myeloma: A Scoping Review

Area of Science:

• Oncology
• Endocrinology
• Epidemiology

Background:

• Global incidence of multiple myeloma (MM) is rising.
• Identifying modifiable risk factors for MM prevention is crucial.
• Pre-clinical evidence suggests vitamin D may influence MM activity and progression.

Purpose of the Study:

• To conduct a structured scoping review of human studies.
• To identify and describe research on the association between vitamin D and MM risk and/or prognosis.

Main Methods:

• Searched OVID-Medline, OVID-Embase, and OVID-Cochrane Library databases.
• Included 15 publications in the review.
• Focused on human-level research.

Main Results:

• Vitamin D deficiency is prevalent in MM patients (42.3%).
• No studies reported on vitamin D status and the risk of developing MM.
• Potential associations with MM staging, neuropathy, and survival require further study.

Conclusions:

• The review mapped existing research on vitamin D and MM.
• Identified knowledge gaps regarding vitamin D's role in MM risk and prognosis.
• Suggests further research into vitamin D, VDR polymorphisms, and MM outcomes.