Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

606
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
606
Oogenesis02:07

Oogenesis

63.9K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.9K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

541
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
541
Ovarian Cycle01:27

Ovarian Cycle

1.5K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

iPSC-Derived iNK Progenitors Engraft and Generate NK Cells in Unconditioned and Autologous Immune Humanized Mice.

Cell proliferation·2026
Same author

Unraveling material characteristics of different pork belly cuts from raw to dish: a comparative study of texture and flavor.

NPJ science of food·2026
Same author

Double-target responsive FRET sensor based on DNA tetrahedron for robust detection of liver fibrosis-related mRNAs in activated hepatic stellate cells.

Biosensors & bioelectronics·2026
Same author

Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models.

Cell stem cell·2026
Same author

Low breakdown field and high ionization index in ReSe<sub>2</sub> avalanche field-effect transistors.

Nature communications·2026
Same author

<i>KIR AA</i> individuals possess strong inhibitory <i>KIR</i> alleles alongside HLA ligands that are protective against leukemia in the Chinese population.

Frontiers in genetics·2026

Related Experiment Video

Updated: Aug 5, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.1K

Regulation of SIRT1 in Ovarian Function: PCOS Treatment.

Xinrong Li1,2, Yuxu He1,2, Shuang Wu1,2

  • 1Department of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.

Current Issues in Molecular Biology
|March 28, 2023
PubMed
Summary

Sirtuins, initially known for longevity, are now studied for their role in ovarian function. This review focuses on SIRT1

Keywords:
SIRT1follicle developmentgranulosa cellsovaryresearch progress

More Related Videos

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

3.0K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.3K

Related Experiment Videos

Last Updated: Aug 5, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.1K
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

3.0K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.3K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Reproductive Biology

Background:

  • Sirtuins are NAD+-dependent histone deacetylases involved in aging and cellular processes.
  • Initially recognized as longevity genes, sirtuins also regulate cell proliferation, apoptosis, and insulin signaling.
  • Recent findings link caloric restriction to increased ovarian reserves, highlighting sirtuins' potential reproductive role.

Purpose of the Study:

  • To review and analyze the role and mechanism of SIRT1 in regulating ovarian function.
  • To explore SIRT1's positive regulatory effects on ovarian function.
  • To investigate the therapeutic potential of SIRT1 in Polycystic Ovary Syndrome (PCOS).

Main Methods:

  • Literature review of existing studies on sirtuins and ovarian function.
  • Analysis of research on SIRT1's molecular mechanisms in the ovary.
  • Examination of studies investigating SIRT1's impact on reproductive capacity and PCOS.

Main Results:

  • Sirtuins, particularly SIRT1, play a significant role in various ovarian physiological processes.
  • SIRT1 demonstrates a positive regulatory effect on ovarian function.
  • Evidence suggests SIRT1 may have therapeutic benefits for PCOS.

Conclusions:

  • SIRT1 is a key regulator of ovarian function with implications for reproductive health.
  • Further research into SIRT1 mechanisms could lead to novel therapeutic strategies for ovarian disorders like PCOS.