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Updated: Aug 5, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Published on: February 28, 2017

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NOTCH Signaling in Osteosarcoma

Zhenhao Zhang1, Wei Wu1, Zengwu Shao1

  • 1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Current Issues in Molecular Biology
|March 28, 2023
PubMed

Insights

The NOTCH pathway is abnormally activated in osteosarcoma, correlating with poor prognosis. Targeting this pathway shows promise for new osteosarcoma treatments, addressing high recurrence and metastasis rates.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Osteosarcoma treatment combining neoadjuvant chemotherapy and surgery has limitations, with high rates of local recurrence and lung metastasis.
  • The NOTCH signaling pathway is implicated in embryonic development and various cancers, including osteosarcoma.
  • Abnormal NOTCH pathway activation is frequently observed in osteosarcoma and linked to poor patient outcomes.

Purpose of the Study:

  • To review the role of the NOTCH signaling pathway in osteosarcoma.
  • To discuss the clinical significance of NOTCH pathway dysfunction in osteosarcoma.
  • To explore the potential of NOTCH-targeted therapy for osteosarcoma treatment.

Main Methods:

  • Literature review of studies on NOTCH pathway composition, biological functions, and clinical significance in osteosarcoma.
  • Analysis of recent research progress in osteosarcoma cell lines and animal models.
  • Evaluation of the clinical application potential of NOTCH-targeted therapies.

Main Results:

  • The NOTCH pathway plays a significant role in osteosarcoma tumorigenesis and progression.
  • NOTCH signaling influences osteosarcoma's biological behavior through diverse molecular mechanisms.
  • NOTCH-targeted therapies have demonstrated potential in preclinical and clinical research for osteosarcoma.

Conclusions:

  • Dysregulation of the NOTCH pathway is a critical factor in osteosarcoma development and prognosis.
  • Targeting the NOTCH pathway represents a promising therapeutic strategy for improving osteosarcoma treatment outcomes.
  • Further research into NOTCH-targeted therapies could lead to more effective treatments for osteosarcoma patients.
Keywords:
NOTCHmolecular targeted therapyosteosarcomaprognosissignaling

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