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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Updated: Aug 5, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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NOTCH Signaling in Osteosarcoma.

Zhenhao Zhang1, Wei Wu1, Zengwu Shao1

  • 1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Current Issues in Molecular Biology
|March 28, 2023
PubMed
Summary
This summary is machine-generated.

The NOTCH pathway is abnormally activated in osteosarcoma, correlating with poor prognosis. Targeting this pathway shows promise for new osteosarcoma treatments, addressing high recurrence and metastasis rates.

Keywords:
NOTCHmolecular targeted therapyosteosarcomaprognosissignaling

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Osteosarcoma treatment combining neoadjuvant chemotherapy and surgery has limitations, with high rates of local recurrence and lung metastasis.
  • The NOTCH signaling pathway is implicated in embryonic development and various cancers, including osteosarcoma.
  • Abnormal NOTCH pathway activation is frequently observed in osteosarcoma and linked to poor patient outcomes.

Purpose of the Study:

  • To review the role of the NOTCH signaling pathway in osteosarcoma.
  • To discuss the clinical significance of NOTCH pathway dysfunction in osteosarcoma.
  • To explore the potential of NOTCH-targeted therapy for osteosarcoma treatment.

Main Methods:

  • Literature review of studies on NOTCH pathway composition, biological functions, and clinical significance in osteosarcoma.
  • Analysis of recent research progress in osteosarcoma cell lines and animal models.
  • Evaluation of the clinical application potential of NOTCH-targeted therapies.

Main Results:

  • The NOTCH pathway plays a significant role in osteosarcoma tumorigenesis and progression.
  • NOTCH signaling influences osteosarcoma's biological behavior through diverse molecular mechanisms.
  • NOTCH-targeted therapies have demonstrated potential in preclinical and clinical research for osteosarcoma.

Conclusions:

  • Dysregulation of the NOTCH pathway is a critical factor in osteosarcoma development and prognosis.
  • Targeting the NOTCH pathway represents a promising therapeutic strategy for improving osteosarcoma treatment outcomes.
  • Further research into NOTCH-targeted therapies could lead to more effective treatments for osteosarcoma patients.