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Recent Advances in Decellularized Matrix-Derived Materials for Bioink and 3D Bioprinting
Huaying Liu1, Yuxuan Gong1, Kaihui Zhang1,2
1College of Life Sciences and Bioengineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing 100091, China.
Gels (Basel, Switzerland)
|March 28, 2023
Summary
Decellularized extracellular matrices (dECM) are revolutionizing 3D bioprinting for tissue engineering. These bioactive materials create biomimetic hydrogels, enabling the construction of complex tissue analogs in vitro.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- 3D bioprinting is an emerging technology with significant potential in tissue engineering and regenerative medicine.
- Decellularized extracellular matrices (dECM) are increasingly used to create tissue-specific bioinks that mimic native microenvironments.
- dECMs are rapidly growing bioactive printing materials essential for cell-based 3D bioprinting.
Purpose of the Study:
- To review methods for preparing and identifying dECMs.
- To outline the characteristic requirements of bioinks for 3D bioprinting.
- To explore recent advances in dECM-derived bioactive printing materials and their applications.
Main Methods:
- Literature review of dECM preparation and characterization techniques.
- Analysis of dECM-based bioink properties and requirements.
- Survey of recent applications in bioprinting various tissues (bone, cartilage, muscle, heart, nervous system).
Main Results:
- dECMs offer a promising strategy for creating biomimetic hydrogels for 3D bioprinting.
- These materials can be used to construct in vitro tissue analogs that resemble native tissues.
- dECM-derived materials have shown diverse applications across multiple tissue types.
Conclusions:
- dECM-based bioactive printing materials hold substantial potential for advancing tissue engineering and regenerative medicine.
- Further research into dECM-derived materials could lead to novel therapeutic strategies.
- The combination of dECMs and 3D bioprinting represents a key future direction in creating functional tissue constructs.
