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Related Experiment Video

Updated: Aug 5, 2025

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
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Reticulocyte Hemoglobin as a Screening Test for Iron Deficiency Anemia: A New Cut-Off.

Abdullah I Aedh1, Mohamed S M Khalil2, Alaa S Abd-Elkader2

  • 1Internal Medicine Department, College of Medicine, Najran University, Najran 55461, Saudi Arabia.

Hematology Reports
|March 28, 2023
PubMed
Summary

Reticulocyte hemoglobin content (Ret-Hb) effectively identifies latent iron deficiency and screens for iron deficiency anemia (IDA). A Ret-Hb level below 21.2 pg indicates IDA, aiding in early diagnosis.

Keywords:
Ret-Hbanemiairon deficiencylatent iron deficiencyreticulocyte

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Area of Science:

  • Hematology
  • Clinical Diagnostics

Background:

  • Latent iron deficiency (LID) presents diagnostic challenges due to depleted iron stores without anemia.
  • Reticulocyte hemoglobin content (Ret-Hb) correlates with iron availability for heme synthesis, making it a potential iron status marker.

Purpose of the Study:

  • To evaluate Reticulocyte hemoglobin content (Ret-Hb) for detecting latent iron deficiency.
  • To assess the utility of Ret-Hb in screening for iron deficiency anemia (IDA).

Main Methods:

  • A study included 108 participants: 64 with iron deficiency anemia (IDA) and 44 with normal hemoglobin.
  • Measurements included complete blood count (CBC), reticulocyte percentage, Ret-Hb, serum iron, TIBC, and serum ferritin.

Main Results:

  • IDA patients showed significantly lower Ret-Hb levels compared to non-anemic individuals.
  • A Ret-Hb cut-off value of 21.2 pg was identified to indicate IDA.

Conclusions:

  • Reticulocyte hemoglobin content (Ret-Hb), alongside CBC, serves as a valuable predictive marker for iron deficiency (ID) and IDA.
  • Adjusting the Ret-Hb cut-off may enhance its role in screening for IDA.