Dissolving Microneedle Patch Integrated with Microspheres for Long-Acting Hair Regrowth Therapy

Area of Science:

• Dermatology
• Biomaterials Science
• Pharmacology

Background:

• Androgenetic alopecia (AGA) is a common cause of hair loss, impacting quality of life.
• Existing treatments like minoxidil and finasteride have limitations including poor bioavailability and side effects.
• There is a need for improved, patient-friendly therapeutic strategies for AGA.

Purpose of the Study:

• To develop a novel, long-acting microneedle (MN) patch for androgenetic alopecia (AGA) treatment.
• To improve drug delivery and reduce administration frequency for minoxidil (MXD).
• To evaluate the efficacy and safety of the MN patch in a preclinical model.

Main Methods:

• Fabrication of a water-soluble MN patch containing biodegradable minoxidil-loaded microspheres (PLGA).
• In vitro and in vivo evaluation of MN patch performance, including drug release kinetics and hair regeneration.
• Comparison of the MN patch with conventional topical minoxidil solutions in AGA mouse models.

Main Results:

• The MN patch enabled sustained release of minoxidil for over two weeks.
• Microneedle application provided mechanical stimulation, aiding hair regrowth.
• The MN patch demonstrated comparable or superior hair regeneration in AGA mice compared to daily topical minoxidil, using a lower drug dose and less frequent administration.

Conclusions:

• The developed microneedle patch is a safe and effective strategy for long-acting androgenetic alopecia treatment.
• This approach offers reduced dosing frequency and enhanced patient compliance.
• The microneedle patch represents a promising alternative to conventional topical treatments for hair loss.