Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

3.0K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
3.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Basicity of Heterocyclic Aromatic Amines01:25

Basicity of Heterocyclic Aromatic Amines

6.2K
Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
6.2K
Acidity of 1-Alkynes02:42

Acidity of 1-Alkynes

9.9K

The acidic strength of hydrocarbons follows the order: Alkynes > Alkenes > Alkanes. The strength of an acid is commonly expressed in units of pKa — the lower the pKa, the stronger the acid. Among the hydrocarbons, terminal alkynes have lower pKa values and are, therefore, more acidic. For example, the pKa values for ethane, ethene, and acetylene are 51, 44, and 25, respectively, as shown here.
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro estimation of human skin permeability and retention and quantitative structure-property analysis of selected chalcones.

Acta chimica Slovenica·2026
Same author

Effect of electronic cigarette aerosols on cisplatin resistance in head and neck cancer cells: a collaborative replication study.

BMC cancer·2026
Same author

Application of the Briggs-Rauscher Oscillatory Reaction for Tartrazine Determination in Food Dye: Spectroscopic, Microscopic, and Analytical Characterization.

Foods (Basel, Switzerland)·2026
Same author

Targeting the Arachidonic Acid Cascade in Cancer: Recent Advances in Enzyme Inhibitor Design.

Anti-cancer agents in medicinal chemistry·2026
Same author

Multifaceted biological and computational assessment of aromatic and N-heteroaromatic non-substituted thiosemicarbazones.

Scientific reports·2026
Same author

Tailored Nitrogen-Doped Laser-Induced Graphene on Novel Synthesized Cross-Linked Aromatic Polyimides for Targeted Applications.

Polymers·2026

Related Experiment Video

Updated: Aug 5, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

7.7K

Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?

Maja Ranković1, Anka Jevremović1, Aleksandra Janošević Ležaić2

  • 1University of Belgrade-Faculty of Physical Chemistry, 11000 Belgrade, Serbia.

Journal of Functional Biomaterials
|March 28, 2023
PubMed
Summary
This summary is machine-generated.

Zeolite Y successfully delivered anticancer agents acridine and its derivatives. Zeolite-supported 9-aminoacridine showed enhanced cancer cell toxicity and favorable drug release, preserving healthy tissues.

Keywords:
acridine derivativesanticancercytotoxicitydrug releasezeolite

More Related Videos

Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5
09:46

Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5

Published on: August 25, 2016

11.7K
Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.5K

Related Experiment Videos

Last Updated: Aug 5, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

7.7K
Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5
09:46

Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5

Published on: August 25, 2016

11.7K
Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.5K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Acridine derivatives are investigated for anticancer properties.
  • Developing effective drug delivery systems is crucial for cancer therapy.
  • Zeolite Y offers a promising nanocarrier platform for drug delivery.

Purpose of the Study:

  • To evaluate acridine and its derivatives (9-chloroacridine, 9-aminoacridine) as anticancer agents delivered via FAU type zeolite Y.
  • To characterize drug loading and release kinetics.
  • To assess the in vitro cytotoxicity of the drug-loaded zeolite system against cancer cells and normal fibroblasts.

Main Methods:

  • Drug loading on zeolite Y was confirmed using FTIR/Raman spectroscopy and electron microscopy.
  • Drug quantification was performed using spectrofluorimetry.
  • In vitro cytotoxicity was assessed using the methylthiazol-tetrazolium (MTT) assay against HCT-116 colorectal carcinoma cells and MRC-5 fibroblasts.

Main Results:

  • Successful and homogeneous drug loading of acridines onto zeolite Y was achieved (18-21 mg/g), preserving zeolite structure.
  • Zeolite-supported 9-aminoacridine exhibited favorable release kinetics in the µM range.
  • The zeolite carrier enhanced the cytotoxic effect of acridines on HCT-116 cells, with 9-aminoacridine showing the highest efficiency.

Conclusions:

  • Zeolite Y serves as an effective carrier for acridine-based anticancer agents.
  • Zeolite-supported 9-aminoacridine demonstrates improved cancer cell toxicity while preserving healthy tissue.
  • The combination of drug-loaded zeolite offers promising potential for anticancer therapeutic applications.