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Alginate-Based Hydrogels and Scaffolds for Biomedical Applications.

Simonida Lj Tomić1, Marija M Babić Radić1, Jovana S Vuković1

  • 1University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia.

Marine Drugs
|March 28, 2023
PubMed
Summary

Alginate hydrogels and scaffolds show promise for tissue regeneration, drug delivery, and cancer treatment. Combining alginate with other materials enhances properties for advanced biomedical applications.

Keywords:
alginatebiomedical applicationshydrogelsscaffolds

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Alginate, a marine-derived polymer, is crucial for developing hydrogels and scaffolds in biomedical engineering.
  • Designing biologically interactive materials is key for effective tissue repair and regeneration.

Purpose of the Study:

  • To review the multifunctional biomedical applications of alginate-based hydrogels and scaffolds.
  • To present novel research on alginate hydrogels combined with various polymers and bioactive agents.

Main Methods:

  • Literature review of alginate applications in dermal regeneration, drug delivery, cancer treatment, and antimicrobials.
  • Experimental synthesis and characterization of alginate-based hydrogels with gelatin, 2-hydroxyethyl methacrylate, apatite, graphene oxide, iron(III) oxide, curcumin, and resveratrol.

Main Results:

  • Alginate hydrogels demonstrate favorable morphology, porosity, absorption, hydrophilicity, mechanical properties, and degradation profiles.
  • In vitro and in vivo biocompatibility assessments confirmed the suitability of these alginate-based materials for biomedical uses.
  • Combinations of alginate with other materials and bioactive agents yielded enhanced properties for specific therapeutic applications.

Conclusions:

  • Alginate is an indispensable biomaterial for creating advanced hydrogels and scaffolds.
  • Alginate-based materials offer significant potential as versatile tools for diverse biomedical applications, including tissue engineering and targeted therapies.