Alkenyl Thioetherification Enabled by Nickel Catalysis
Bing Xu1,2, Huan Xiang1,2, Yuqiong Tan1,2
1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
Abstract:
This paper describes an efficient strategy to promote alkenyl thioetherifications via the Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols. The present strategy with easy-to-operate reaction conditions represents one of the most effective alkenyl C(sp2)-S bond-forming methods via readily accessible nickel catalysis. Notably, the mildly basic conditions employed facilitate access to a broad scope including protected amino acids, saccharides, and heterocycles. Moreover, this work presents its attractive usefulness by the application in late-stage modifications of several structurally complex natural products and pharmaceuticals.
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