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[Interleukin-11 in Pathologies of the Nervous System].

M I Airapetov1,2, S O Eresko2,3,4, P D Ignatova1

  • 1Department of Pharmacology, St. Petersburg State Pediatric Medical University, St. Petersburg, 194044 Russia.

Molekuliarnaia Biologiia
|March 28, 2023
PubMed
Summary

Interleukin 11 (IL-11) is a cytokine with potential therapeutic applications. Research indicates its role in correcting inflammatory pathways and its involvement in brain pathologies, suggesting future clinical use.

Keywords:
IL-11IL-6 familybraingp130neurodegenerationneuroinflammation

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Area of Science:

  • Biomedicine
  • Neuroscience
  • Immunology

Background:

  • Cytokines are crucial in pathological conditions, with Interleukin 11 (IL-11) gaining recent attention.
  • IL-11 demonstrates potential in modulating inflammatory pathways, particularly in respiratory epithelial tissues affected by SARS-CoV-2.
  • IL-11 is endogenously expressed in the central nervous system, implicating it in neurological functions.

Approach:

  • This review synthesizes existing experimental data on IL-11's role in the nervous system.
  • Focuses on the mechanisms underlying IL-11's involvement in the development of brain pathologies.
  • Analyzes the current understanding of IL-11's physiological and pathological significance.

Key Points:

  • IL-11 plays a significant role in the central nervous system, with local expression by nerve cells.
  • Studies link IL-11 to the pathogenesis of various neurological disorders.
  • IL-11's ability to correct inflammatory pathways suggests therapeutic potential.

Conclusions:

  • IL-11 is implicated in the mechanisms driving brain pathologies.
  • Further research into IL-11's functions may lead to novel therapeutic strategies for neurological conditions.
  • The cytokine is poised for clinical application in managing nervous system disorders.