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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome
Doug Brugge1, Jianghong Li2, Wig Zamore3
1Department of Public Health Sciences, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.
Toxics
|March 28, 2023
Abstract:
Particulate matter air pollution is associated with blood inflammatory biomarkers, however, the biological pathways from exposure to periferal inflammation are not well understood. We propose that the NLRP3 inflammasome is likely stimulated by ambient particulate matter, as it is by some other particles and call for more research into this pathway.

