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Superior colliculus lesions and flash evoked potentials from rat cortex.

M I Barnes, R S Dyer

    Brain Research Bulletin
    |February 1, 1986
    PubMed
    Summary
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    The superior colliculus (SC) does not generate the secondary flash evoked potential (FEP) response in rats. However, SC lesions modulated the amplitude of the N2P3 component of the FEP.

    Area of Science:

    • Neuroscience
    • Visual Processing
    • Electrophysiology

    Background:

    • The retino-geniculate pathway is traditionally considered the primary source of the rat flash evoked potential (FEP).
    • The secondary FEP response was hypothesized to involve input from the superior colliculus (SC) or other brainstem structures to the visual cortex.

    Purpose of the Study:

    • To investigate the role of the superior colliculus (SC) in the generation and modulation of the rat flash evoked potential (FEP).
    • To determine if SC input is essential for the secondary response component of the FEP.

    Main Methods:

    • Male Long-Evans rats underwent surgical implantation of electrodes in the visual cortex.
    • Electrolytic lesions were created in the SC of experimental groups; control groups received no lesions.

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  • Flash evoked potentials (FEPs) were recorded before and after SC lesioning, with histological verification of lesion extent.

    • Main Results:

    • Massive electrolytic lesions of the SC did not abolish any part of the rat FEP.
    • SC lesions resulted in a significant amplitude increase of the N2P3 component of the FEP.
    • No decrement in FEP was observed, indicating the SC is not the generator of the secondary response.

    Conclusions:

    • The superior colliculus (SC) is not the primary generator of the secondary flash evoked potential (FEP) response in rats.
    • The SC appears to play a modulatory role, influencing the amplitude of specific FEP components like N2P3.