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Obstructive sleep apnoea and glaucoma: a systematic review and meta-analysis.
Alex Jia Yang Cheong1, Sean Kang Xuan Wang1, Chang Yi Woon1
1Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Eye (London, England)
|March 28, 2023
Summary
Obstructive sleep apnoea (OSA) is linked to a significantly higher risk of glaucoma. This meta-analysis confirms the association, finding up to 40% increased odds of glaucoma in OSA patients.
Area of Science:
- Ophthalmology
- Sleep Medicine
- Public Health
Background:
- Conflicting studies exist on the association between obstructive sleep apnoea (OSA) and glaucoma.
- Previous meta-analyses may not reflect recent research, necessitating an updated analysis.
Approach:
- Systematic review and meta-analysis of observational and cross-sectional studies.
- Searched major databases (PubMed, Embase, Scopus, Cochrane) up to February 2022.
- Utilized Newcastle-Ottawa scale for quality assessment and GRADE for evidence evaluation.
Key Points:
- 48 studies with 4,566,984 patients were included.
- OSA was associated with a 3.66-fold increased risk of glaucoma (95% CI 1.70-7.90).
- Even after adjusting for confounders, OSA patients had up to 40% higher odds of glaucoma.
Conclusions:
- Obstructive sleep apnoea is associated with an increased risk and severity of glaucoma.
- Further clinical research on OSA treatment's effect on glaucoma progression is recommended.
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