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Updated: Aug 5, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Methacrylate Cationic Nanoparticles Activity against Different Gram-Positive Bacteria.

Syong H Nam-Cha¹, Ana V Ocaña², Ramón Pérez-Tanoira^3,4

¹Department of Pathology, Complejo Hospitalario Universitario, 02006 Albacete, Spain.

Antibiotics (Basel, Switzerland)

|March 29, 2023

Summary

Nanoparticles (NPs) with 2-(dimethylamino)ethyl methacrylate (DMAEMA) show antibacterial properties against common clinical strains. However, increasing methylmethacrylate (MMA) concentrations reduced effectiveness without affecting cytotoxicity.

Keywords:

DMAEMA MMA antibacterial activity nanoparticles

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Area of Science:

Nanotechnology
Materials Science
Microbiology

Background:

Nanoparticles (NPs) possess antimicrobial properties, offering potential in combating bacterial infections.
2-(dimethylamino)ethyl methacrylate (DMAEMA) is explored as a functional group for enhancing NP antimicrobial capabilities.

Purpose of the Study:

To investigate the antibacterial efficacy of quaternised NPs anchored with DMAEMA.
To evaluate the impact of methylmethacrylate (MMA) copolymerization on the antibacterial activity and cytotoxicity of these NPs.

Main Methods:

Synthesis of three quaternised NPs anchored with DMAEMA.
Copolymerization of NPs with varying concentrations of MMA.
Assessment of antibacterial activity against *Staphylococcus aureus*, *S. epidermidis*, *S. lugdunensis*, and *Enterococcus faecalis* using Minimal Inhibitory Concentration (MIC).
Evaluation of cytotoxicity in NIH$_{3}$T$_{3}$ mouse fibroblast cultures via MTT assays.

Main Results:

All synthesized NPs demonstrated effectiveness against the tested bacterial strains.
Higher MMA concentrations during synthesis led to a decrease in antibacterial activity.
Cytotoxicity remained unchanged across different MMA concentrations.

Conclusions:

NPs anchored with DMAEMA exhibit promising antibacterial potential.
MMA incorporation negatively impacts the antibacterial efficacy of DMAEMA-anchored NPs.
Further research involving diverse copolymers is recommended to optimize the antibacterial performance of DMAEMA-anchored NPs.