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Oxidative Stress and Cardiovascular Risk Factors: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Amir S Heravi1, Di Zhao2, Erin D Michos1
1School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Antioxidants (Basel, Switzerland)
|March 29, 2023
Summary
This study found higher oxidative stress markers in women and individuals with higher BMI, smoking, and lower physical activity. Different isoprostane measures offer complementary insights into cardiovascular disease risk factors.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Public Health
Background:
- Oxidative stress is implicated in cardiovascular diseases (CVD) and may differ between sexes.
- Few population studies exist, especially in younger, healthier cohorts with advanced CVD.
Purpose of the Study:
- To assess urinary isoprostane concentrations in a young, healthy cohort.
- To investigate associations between oxidative stress, cardiometabolic profile, and sex.
Main Methods:
- Measured urinary 8-isoprostane (IsoP) and 2,3-dinor-8-isoprostane (IsoP-M) in 475 women and 266 men (aged 48-55).
- Used multivariable-adjusted regression for cross-sectional analysis.
- Analyzed plasma F2-isoprostanes (plasma IsoP) in a subset.
Main Results:
- Women exhibited higher median urinary IsoP and IsoP-M compared to men.
- Higher oxidative stress correlated with increased BMI, triglycerides, smoking, and reduced physical activity.
- Diabetes showed varied associations with different isoprostane measures.
Conclusions:
- Urinary and plasma isoprostanes provide complementary, not interchangeable, assessments of oxidative stress.
- Higher isoprostane levels in women, smokers, less active individuals, and those with higher BMI/triglycerides suggest elevated oxidative stress in these groups.
- Care is needed when comparing urinary isoprostanes between groups with differing serum creatinine levels.
Keywords:
2,3-dinor-8-isoprostane8-isoprostanecardiovascular disease risk factorsoxidative stressurinary isoprostanesMore Related Videos
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