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Telomere Attrition in Chronic Kidney Diseases
Tina Levstek1,2, Katarina Trebušak Podkrajšek1,2
1Laboratory for Translational Medical Biochemistry, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.
Antioxidants (Basel, Switzerland)
|March 29, 2023
Summary
Telomere length shortens with cell division and oxidative stress, contributing to chronic kidney diseases (CKDs). Shorter telomeres correlate with reduced kidney function and disease progression.
Area of Science:
- Genetics
- Nephrology
- Cell Biology
Background:
- Telomeres protect chromosome ends but shorten with cell division.
- Critically short telomeres induce senescence, linked to age-related diseases like CKD.
- Oxidative stress accelerates telomere shortening due to high guanine content.
Purpose of the Study:
- To review studies on telomere length (TL) in CKD patients.
- To highlight the association between TL and CKD development and progression.
- To examine TL in patients undergoing kidney replacement therapy.
Main Methods:
- Comprehensive literature review of studies on telomere length and CKD.
- Focus on human studies, including those with kidney replacement therapy.
- Analysis of mechanisms linking TL and kidney disease pathophysiology.
Main Results:
- Shorter TL is associated with decreased kidney function and nephropathy progression.
- Hemodialysis accelerates telomere attrition.
- Telomere lengthening observed in some longitudinal studies.
- Uremic environment persists post-kidney transplantation.
Conclusions:
- Telomere attrition is implicated in the pathophysiology of kidney disease.
- Understanding this link may lead to new CKD management strategies.
- Further research is needed to elucidate the complex relationship between TL and CKD.
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