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Updated: Aug 5, 2025

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Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

Somayyeh Ghareghomi1, Faezeh Moosavi-Movahedi1, Luciano Saso2

  • 1Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, Iran.

Antioxidants (Basel, Switzerland)
|March 29, 2023
PubMed

Insights

Natural antioxidants target the Nrf2/HO-1 pathway to combat lung cancer. This cytoprotective pathway offers dual benefits, making it a novel strategy for cancer treatment by regulating antioxidant enzymes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Oxidative stress (OS) contributes to various pathophysiological conditions.
  • The Keap1/Nrf2 pathway is a master regulator of cellular antioxidant responses.
  • This pathway exhibits duality, offering benefits to both normal and cancer cells.

Purpose of the Study:

  • To investigate the molecular mechanisms of natural antioxidants in lung cancer.
  • To explore the role of the Nrf2/HO-1 axis in this context.
  • To evaluate Nrf2/HO-1 axis targeting as a potential cancer therapy.

Main Methods:

  • Literature review focusing on the Keap1/Nrf2 pathway.
  • Analysis of molecular mechanisms of natural antioxidants.
  • Examination of the Nrf2/HO-1 axis in lung cancer.

Main Results:

  • The Keap1/Nrf2 pathway regulates antioxidant enzymes, including heme oxygenase-1 (HO-1).
  • HO-1 serves as an indicator of the pathway's dual role in cancer.
  • Targeting the Nrf2/HO-1 axis is a promising strategy for lung cancer treatment.

Conclusions:

  • Natural antioxidants modulate the Nrf2/HO-1 axis in lung cancer cells.
  • The Nrf2/HO-1 pathway represents a significant therapeutic target for lung cancer.
  • Further research into Nrf2/HO-1 targeting could lead to novel cancer treatments.
Keywords:
Heme oxygenase-1Keap/Nrf2 pathwayantioxidantslung canceroxidative stress

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