Jove
Visualize
Contact Us

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

34.4K
The Concept of Multiple Allelism
34.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

316
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
316
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.6K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Entropies of the Classical Dimer Model.

Entropy (Basel, Switzerland)·2025
Same author

Entropy of Charge Inversion in DNA including One-Loop Fluctuations.

Entropy (Basel, Switzerland)·2023
Same author

More of the same? Voxelotor spawns a successor, but on what success does it build?

British journal of haematology·2023
Same author

More to voxelotor than meets the eye?

Blood advances·2022
Same author

Water, Ions, and Hemoglobin: Effects on Allostery and Polymerization.

The journal of physical chemistry. B·2018
Same journal

Correction: Reis et al. Bioinks Enriched with ECM Components Obtained by Supercritical Extraction. <i>Biomolecules</i> 2022, <i>12</i>, 394.

Biomolecules·2026
Same journal

Correction: Kim, K.-H.; Yoo, B.C. Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. <i>Biomolecules</i> 2026, <i>16</i>, 465.

Biomolecules·2026
Same journal

Correction: Bastyte et al. The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy. <i>Biomolecules</i> 2024, <i>14</i>, 212.

Biomolecules·2026
Same journal

AtHSPR Plays a Positive Role in Arabidopsis Resistance Against <i>Pseudomonas syringae</i> pv. <i>tomato</i> DC3000 by Interacting with TOP1.

Biomolecules·2026
Same journal

CYTH4 Facilitates Renal Cell Carcinoma via Enhancing Proliferation and Likely Immune Evasion.

Biomolecules·2026
Same journal

Integrated Immune-Gut Profiling Identifies an Exploratory Pediatric Inflammatory Intestinal Profile Associated with Food-Specific IgG Reactivity.

Biomolecules·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 5, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.9K

The Sickle-Cell Fiber Revisited.

Marilyn F Bishop1, Frank A Ferrone2

  • 1Department of Physics, Virginia Commonwealth University, Richmond, VA 23284, USA.

Biomolecules
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

Sickle cell disease arises from a hemoglobin mutation causing rigid polymer formation. Newer research refines the understanding of these polymer structures and their impact on circulation.

Keywords:
double strandelectron microscopysickle cell polymer

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.5K

Related Experiment Videos

Last Updated: Aug 5, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.9K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.5K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Hematology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder caused by a point mutation in the hemoglobin-beta gene.
  • This mutation leads to the formation of abnormal, rigid hemoglobin polymers within red blood cells.
  • These polymers distort red blood cell shape, causing vaso-occlusion and diverse SCD complications.

Purpose of the Study:

  • To review recent advancements in understanding the molecular structure of sickle cell polymers.
  • To elaborate on the established model of polymer formation in sickle cell disease.
  • To provide deeper insights into the mechanisms underlying polymer assembly and its pathological consequences.

Main Methods:

  • Review of existing literature on sickle cell hemoglobin polymerization.
  • Analysis of structural data from crystallographic and spectroscopic studies.
  • Integration of newer findings with established polymerization models.

Main Results:

  • The review elaborates on the seven-paired double-strand model of sickle cell polymers.
  • Newer developments provide refined structural details and insights into polymer assembly dynamics.
  • These advancements offer a more comprehensive understanding of the polymerization process at a molecular level.

Conclusions:

  • Recent research offers a more nuanced view of sickle cell polymer structure beyond the initial model.
  • Understanding these complex structures is crucial for developing targeted therapeutic strategies for sickle cell disease.
  • Continued investigation into polymer dynamics may reveal new avenues for disease intervention.