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Published on: November 5, 2019
The Sickle-Cell Fiber Revisited
Marilyn F Bishop1, Frank A Ferrone2
1Department of Physics, Virginia Commonwealth University, Richmond, VA 23284, USA.
Abstract:
Sickle cell disease is the consequence of a single point mutation on the surface of the β chains of the hemoglobin molecule leading to the formation of rigid polymers that disrupt circulation. It has long been established that the polymers are comprised of seven pairs of double strands that are twisted replicas of the double strands found in crystals. Here, we review several newer developments that elaborate on that simple model and provide deeper insights into the process.
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