Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Susceptibility to carcinogenesis.

A E Reif

    Cancer
    |June 15, 1986
    PubMed
    Summary

    The spontaneous incidence of a tumor type influences carcinogen-induced tumor rates. Carcinogen testing is most sensitive when spontaneous tumor incidence is low or subthreshold.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Consensus on synergism between cigarette smoke and other environmental carcinogens in the causation of lung cancer.

    Advances in cancer research·1999
    Same author

    Heredity as a determining factor in which smokers die of lung cancer.

    Journal of the National Cancer Institute·1991
    Same author

    The discovery of Thy-1 and its development.

    Immunology series·1989
    Same author

    Relationship of success in classical immunotherapy to the relative immunorejective strength of the tumor.

    Journal of the National Cancer Institute·1986
    Same author

    Relationship of macrophage content, immunogenicity, and metastatic potential of a murine osteosarcoma of recent origin.

    Clinical & experimental metastasis·1985
    Same author

    Vaccination of adult and newborn mice of a resistant strain (C57BL/6J) against challenge with leukemias induced by Moloney murine leukemia virus.

    Cancer research·1985

    Area of Science:

    • Oncology
    • Carcinogenesis Research

    Background:

    • The relationship between spontaneous tumor incidence and carcinogen-induced tumors is complex.
    • Previous reviews have analyzed related subjects, necessitating a re-examination of data to avoid bias.

    Purpose of the Study:

    • To investigate the influence of spontaneous tumor incidence on carcinogen-induced tumor rates.
    • To mathematically eliminate confounding factors affecting carcinogenesis.
    • To determine optimal conditions for carcinogen assays.

    Main Methods:

    • Analysis of qualitative and quantitative evidence from a previous review.
    • Mathematical elimination of factors influencing carcinogenesis.
    • Examination of unselected carcinogenesis data.

    Main Results:

    • Spontaneous tumor incidence can be a factor in carcinogen-induced tumor rates.
    • When other factors are not eliminated, spontaneous incidence may appear to have no effect.
    • Carcinogens enhance the conversion of normal cells to cancer cells.

    Conclusions:

    • Spontaneous tumor incidence is a weak factor with incomplete penetrance, often outweighed by other factors.
    • Carcinogen assays are most sensitive when the target tumor type has a low or subthreshold spontaneous incidence.
    • Further evidence is needed to definitively prove this relationship.

    Related Experiment Videos