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Related Experiment Videos

Susceptibility to carcinogenesis.

A E Reif

    Cancer
    |June 15, 1986
    PubMed
    Summary
    This summary is machine-generated.

    The spontaneous incidence of a tumor type influences carcinogen-induced tumor rates. Carcinogen testing is most sensitive when spontaneous tumor incidence is low or subthreshold.

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    Area of Science:

    • Oncology
    • Carcinogenesis Research

    Background:

    • The relationship between spontaneous tumor incidence and carcinogen-induced tumors is complex.
    • Previous reviews have analyzed related subjects, necessitating a re-examination of data to avoid bias.

    Purpose of the Study:

    • To investigate the influence of spontaneous tumor incidence on carcinogen-induced tumor rates.
    • To mathematically eliminate confounding factors affecting carcinogenesis.
    • To determine optimal conditions for carcinogen assays.

    Main Methods:

    • Analysis of qualitative and quantitative evidence from a previous review.
    • Mathematical elimination of factors influencing carcinogenesis.
    • Examination of unselected carcinogenesis data.

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    Main Results:

    • Spontaneous tumor incidence can be a factor in carcinogen-induced tumor rates.
    • When other factors are not eliminated, spontaneous incidence may appear to have no effect.
    • Carcinogens enhance the conversion of normal cells to cancer cells.

    Conclusions:

    • Spontaneous tumor incidence is a weak factor with incomplete penetrance, often outweighed by other factors.
    • Carcinogen assays are most sensitive when the target tumor type has a low or subthreshold spontaneous incidence.
    • Further evidence is needed to definitively prove this relationship.