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Distinct Roles of SELENOF in Different Human Cancers.

Brenna Flowers1, Oliwia Bochnacka1, Allison Poles1

  • 1Department of Cancer Biology, Loyola University Chicago, Maywood, IL 60153, USA.

Biomolecules
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

SELENOF (SEP15) is a selenoprotein involved in metabolism and redox control. Its altered expression impacts cancer development, potentially contributing to prostate and breast cancer but protecting against colon cancer.

Keywords:
SELENOFcancerenergy metabolismredox protein quality controlselenoprotein F

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • SELENOF (SEP15) is a selenoprotein essential for cellular functions.
  • Its expression is altered in various cancers, prompting investigation into its role in carcinogenesis.
  • Understanding SELENOF's function is crucial for cancer research.

Purpose of the Study:

  • To review the discovery, structure, localization, and expression of SELENOF.
  • To summarize SELENOF's known molecular functions, including its role in metabolism and redox control.
  • To analyze the association between SELENOF and cancer risk and outcome.

Main Methods:

  • Literature review of published data on SELENOF.
  • Analysis of SELENOF's molecular function and cellular localization.
  • Examination of genetic variations in the SELENOF gene.

Main Results:

  • SELENOF is a thioredoxin-like protein involved in redox protein quality control.
  • It plays a role in regulating lipids, glucose, and energy metabolism.
  • Loss of SELENOF is linked to prostate and breast cancer development, but may be protective against colon cancer.

Conclusions:

  • SELENOF has a significant role in cellular metabolism and redox homeostasis.
  • Its expression levels and genetic variations are associated with differential cancer risks.
  • Further research into SELENOF's mechanisms is warranted to understand its full impact on cancer.